Biotics Research Methylfolate Plus™

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Biotics Research Methylfolate Plus™ (120 tablets)

Methylfolate Plus™ supplies folate, in the active form of (6S)-5-Methyltetrahydrofolic acid, glucosamine salt. Methylfolate is a highly absorbable, activated form of folate, which does not require enzymatic conversion to 5-methylfolate in the body. The glucosamine salt form utilized in Methylfolate Plus™ is more stable than other forms of methylfolate often used. Folate deficiency is one of the most common vitamin deficiencies. In individuals with homozygous (TT) or heterozygous (CT) genetic predisposition, eating folate-rich foods may not provide the recommended daily dosage of folate, thus the need for supplementation. By providing 5-methylfolate directly, Methylfolate Plus™ may have benefits for those who do not produce enough 5-methylfolate in response to folic acid supplementation. Each serving (½ tablet) of Methylfolate Plus™ supplies 400 mcg of folate as 5-methylfolate, combined with 25 mcg of vitamin B12 as methylcobalamin in our biologically active, phytochemically rich vegetable culture base.

Key Benefits

  • Assists in the essential process of methylation
  • Benefits individuals who do not produce enough 5-methylfolate 
  • Supports the battle against symptoms of undermethylation or B12 deficiency like anxiety, IBS, headaches, among others


Folate (as (6S)-5-methyltetrahydrofolic acid, glucosamine salt), Vitamin B12 (as methylcobalamin). Vegetable culture†, methylcellulose, stearic acid (vegetable source), magnesium stearate (vegetable source), pharmaceutical glaze

†Specially grown, biologically active vegetable culture containing methyl compounds and/or naturally associated phytochemicals including polyphenolic compounds with SOD and catalase, dehydrated at low temperature to preserve associated enzyme factors. 

Allergy Information: Non GMO, gluten free, dairy free

Suggested Use

Take one half (½) tablet each day as a dietary supplement or as otherwise directed by a healthcare professional. 


These statements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.